NDLI: Theoretical investigation of the effects of timing calibration errors on time-of-flight PET image quality

Content Provider	IEEE Xplore Digital Library
Author	Manjeshwar, Ravindra Asma, Evren
Copyright Year	2008
Description	Author affiliation: Functional Imaging Laboratory, General Electric Global Research Center, Niskayuna, NY 12309, USA (Manjeshwar, Ravindra; Asma, Evren)
Abstract	Miscalibration of Time-of-Flight (TOF) PET systems can result in significant degradation in reconstructed image quality. We present two expressions for pixel-wise image covariance estimation in the presence of mismatch between the acquisition and reconstruction system models.We applied these two approaches to investigate the effect of calibration errors in the timing delay across detectors. We simulated a 200ps coincidence timing resolution TOF-PET system with nominally no timing delays across detectors. We simulated four uncalibrated systems where the timing delay across detectors were Gaussian distributed with zero mean and standard deviations of 50, 100, 200, and 300 ps. We generated sinograms for a 45cm x 30cm elliptical phantom with two lesions using forward projectors that modeled the 4 uncalibrated systems. The two methods resulted in similar estimates of image noise when the calibration errors were small but produced very different estimates for large calibration errors. To verify the accuracy of the two approaches we estimated the image variance using Monte Carlo simulations for the systems with 50 and 300 ps timing delay calibration error. The second approximation, which is based on expanding the Taylor series around the actual data mean, showed good agreement with Monte-Carlo simulations and was found to be more accurate for large calibration errors.
Starting Page	5175
Ending Page	5178
File Size	2574142
Page Count	4
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774401
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Timing Calibration Positron emission tomography Image quality Delay estimation Detectors Image reconstruction Degradation Pixel Delay effects
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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