NDLI: Geometric co-calibration of a small animal SPECT-CT system with fully superimposed fields-of-view

Content Provider	IEEE Xplore Digital Library
Author	Liji Cao, Kriesche, Thomas Peter, Jorg
Copyright Year	2008
Description	Author affiliation: German Cancer Research Center (DKFZ), Div. Medical Physics in Radiation, Im Neuenheimer Feld 280, Heidelberg, D-69120, Germany (Liji Cao,; Kriesche, Thomas; Peter, Jorg)
Abstract	In this paper we present a method for geometric co-calibration of a single-gantry SPECT-CT small animal imaging system with axially overlapping fields-of-view. Because spatial resolution and noise level differ greatly between both sub-systems the method incorporates different strategies to obtain more accurate calibration values. Firstly, x-ray tomographic calibration is performed on a steel-sphere-phantom which includes 13 steel spheres with 1 mm in diameter, placed on a straight line. Geometric displacement for the high-resolution x-ray CT system (five parameters) is then calculated based on a mathematical analysis of those projection data. Secondly, a 360 degree SPECT-CT imaging of point sources, which are labeled with both radioactivity and x-ray absorber, is applied. With the calculated geometric parameters for the CT system the exact positions of the point sources in the CT volume can be extracted from the CT reconstruction result, and given the positional information in CT as a priori the geometric displacement for the SPECT camera as well as the intrinsic co-alignment between the SPECT and the CT sub-systems (six parameters) is estimated with an iterative optimization strategy (Levenberg-Marquardt). For routine imaging, the calibrated parameters are incorporated into the image reconstruction algorithms applied to the SPECT (MLEM) and CT (FDK) data, respectively, without an additional registration process. Our results show intrinsically aligned images of both modalities with high spatial resolution and low level of mis-alignment. This method is feasible for multi-modality imaging systems with common fields-of-view, however, large difference in spatial resolution and noise level.
Starting Page	3779
Ending Page	3785
File Size	6635491
Page Count	7
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774280
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals Computed tomography Spatial resolution X-ray imaging High-resolution imaging Optical imaging Noise level Calibration Image reconstruction Steel co-calibration SPECT CT
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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