NDLI: Quantitation of D2 receptor binding with dedicated small animal PET, small animal SPECT and HiSPECT - the impact of the reference region on the binding potential

Content Provider	IEEE Xplore Digital Library
Author	Nikolaus, Susanne Wirrwar, Andreas Viehover, Sandra Azmoudeh, Afsaneh Larisch, Rolf Beu, Markus Antke, Christina Schramm, Nils U. Muller, Hans-Wilhelm
Copyright Year	2008
Description	Author affiliation: Clinic of Nuclear Medicine, University Hospital Düsseldorf, 40225, Germany (Nikolaus, Susanne; Wirrwar, Andreas; Viehover, Sandra; Azmoudeh, Afsaneh; Beu, Markus; Antke, Christina; Muller, Hans-Wilhelm) \|\| Central Laboratory of Electronics, Research Center Jülich, 52428, Germany (Schramm, Nils U.) \|\| Clinic of Nuclear Medicine at the Clinic of Lüdenscheid, 58515, Germany (Larisch, Rolf)
Abstract	In this study, we assess the impact of the reference tissue (frontal cortex, parietal cortex, cerebellum) on the magnitude of the binding potential obtained for the D2 receptor ligands [18F]N-methyl-benperidol and [123I]iodobenzamide in the rat striatum using dedicated small animal PET (“TierPET”), small animal SPECT (“TierSPECT”) or a conventional dual-head SPECT camera upgraded with multipinhole-collimators (“HiSPECT”). With all 3 cameras employed in our investigation, striatum-to-cerebellum ratios were consistently higher compared to striatum-to-cortex ratios. Moreover, frontal-cortex-to-cerebellum ratios tended to exceeded parietal-cortex-tocerebellum. Findings are in line with previous in vitro results, and show that quantitation of both striatal and cortical D2 receptor binding is feasible using small animal imaging devices including the novel HiSPECT. With HiSPECT, both striatum-to-cortex and striatum-to-cerebellum ratios of IBZM were higher compared to TierSPECT, which underlines the greater suitability of the higher resolving camera. Findings, moreover, imply that the reference tissue should be carefully chosen with respect to the intended investigation.
Starting Page	4241
Ending Page	4245
File Size	6022589
Page Count	5
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774218
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals Positron emission tomography Cameras Laboratories Rats Telephony Extraterrestrial measurements Image reconstruction Collimators Parkinson's disease
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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