NDLI: Image quality improvements with time-of-flight positron emission tomography for molecular imaging

Content Provider	IEEE Xplore Digital Library
Author	Manjeshwar, R.M. Yiping Shao Jansen, F.P.
Copyright Year	2005
Description	Author affiliation: Functional Imaging, GE Global Res. Center, Niskayuna, NY, USA (Manjeshwar, R.M.; Yiping Shao; Jansen, F.P.)
Abstract	The renewed interest in time of flight (TOF) PET is being driven by the development of detector technology and the growth of new molecular imaging applications. In this study we performed Monte Carlo simulations to quantify image quality improvements as a function of timing resolution for imaging scenarios that mimic whole body and brain imaging. We implemented an iterative image reconstruction algorithm that incorporated time-of-flight information. Image quality, as measured through contrast and noise metrics, consistently improved with improved timing resolution. We simulated and compared a conventional PET scanner with a TOF-PET scanner with 200 ps timing resolution. For lesions embedded in 40 cm and 20 cm cylindrical objects, lesion contrast improved by a factor of 3.4 and 2.3, respectively. TOF-PET holds the potential for significantly improved imaging over conventional PET scanners of equivalent sensitivity.
Sponsorship	IEEE Signal Processing Soc
File Size	323733
File Format	PDF
ISBN	0780388747
ISSN	15206149
DOI	10.1109/ICASSP.2005.1416438
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-03-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image quality Positron emission tomography Molecular imaging Timing Whole-body PET Image resolution Lesions Detectors Brain Image reconstruction
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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