NDLI: Initial performance assessment of a combined microPET® focus-F120 and MR split magnet system

Content Provider	IEEE Xplore Digital Library
Author	Hawkes, Rob C. Fryer, Tim D. Lucas, Alun J. Siegel, Stefan B. Ansorge, Richard E. Clark, John C. Carpenter, T. Adrian
Copyright Year	2008
Description	Author affiliation: Department of Physics, University of Cambridge, J.J. Thomson Avenue, CB3 0HE, USA (Ansorge, Richard E.) \|\| Wolfson Brain Imaging Centre, University of Cambridge, Box 65, Addenbrooke¿s Hospital, CB2 0QQ, UK (Hawkes, Rob C.; Fryer, Tim D.; Lucas, Alun J.; Clark, John C.; Carpenter, T. Adrian) \|\| Siemens Molecular Imaging Preclinical Solutions, 810 Innovation Drive, Knoxville, TN 37932, USA (Siegel, Stefan B.)
Abstract	This work is an initial evaluation of the performance of a microPET Focus-Fl20 system modified to fit in the split in a 1 Tesla MR imaging system to create a rodent scanner capable of simultaneous PET and MR acquisition. The MR imager is a novel design with a split in the magnet former, cryostat and gradient coils and with sufficient self-shielding to radically reduce the stray field at the cryostat edge. This permits the Focus-F120 detector geometry to be maintained with the addition of longer fibre bundles coupling the crystals to the PMT’s, which consequently are situated in a low magnetic field region outside the cryostat. Baseline PET performance was measured with gradient and shim coils in place but without RF coils in the PET FOV. Misalignment of the crystal blocks has decreased the PET spatial resolution, from 1.7 mm to 2.2 mm at 5 mm radial distance, compared to the Focus-F120. The peak absolute sensitivity is reduced to 5.3% compared to 6.8% for a 250-750 keV energy window and 6 ns coincidence window. The noise equivalent count rate (NECR-1R) peaks at about 215 kcps at 112 MBq for a NEMA rat phantom compared to 300 kcps for the Focus-F120 at 140 MBq. Magnetic field homogeneity was assessed as +/− 6 hertz over a 10 cm long and 8 cm diameter cylindrical space and a pulsed gradient strength of 200 mT/m, with a rise time of less than 100 microseconds, demonstrated on all three axes. Separate PET and MR imaging capability has been demonstrated as well as continuous, simultaneous acquisition with no detectable interference between the two imaging systems.
Starting Page	3673
Ending Page	3678
File Size	22045084
Page Count	6
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774113
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Focusing Positron emission tomography Coils Magnetic field measurement Rodents Magnetic separation Image edge detection Detectors Geometry Couplings
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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