NDLI: Towards quantitative SPECT: Error estimation of SPECT OSEM with 3D resolution recovery, attenuation correction and scatter correction

Content Provider	IEEE Xplore Digital Library
Author	Zeintl, J. Vija, A. H. Yahil, A. Ding, X. Hornegger, J. Kuwert, T.
Copyright Year	2008
Description	Author affiliation: University of Erlangen-Nuremberg, Clinic of Nuclear Medicine, Germany (Kuwert, T.) \|\| Siemens Medical Solution USA, Inc., Molecular Imaging, Hoffman Estates, IL 60192, USA (Vija, A. H.; Ding, X.) \|\| University of Erlangen-Nuremberg, Institute of Pattern Recognition, Germany (Zeintl, J.; Hornegger, J.) \|\| Image Recon LLC, Stony Brook, NY, USA (Yahil, A.)
Abstract	In this study we systematically investigate biases relevant to quantitative SPECT if OSEM with isotropic (3D) depth dependent resolution recovery (OSEM-3D), attenuation and scatter correction is used. We focus on the dependencies of activity estimation errors on the projection operator, structure size, pixel size, count density and reconstruction parameters. We use Tc-99m to establish a base line. Four Siemens low energy collimators (Low Energy Ultra High Resolution, Low Energy High Resolution, Low Energy All Purpose, Low Energy High Sensitivity) with geometric resolution between 4.4 mm and 13.1 mm at 10 cm distance and sensitivity between 100 cpm/μCi and 1020 cpm/μCi are tested with simulations of spheres with diameters between 9.8 mm and 168 mm in background. Pixel sizes and total counts are varied between 2.4 mm and 9.6 mm and 0.125 and 32 million counts. Images are reconstructed with OSEM-3D (Flash3D) with attenuation and scatter correction. Emission recovery is quantitatively measured for different reconstruction parameter settings. In addition, physical measurements of standard quality control phantoms are performed using an actual SPECT/CT system (Symbia® T6). Cross calibration of the imaging system with a well counter and results from simulations are used to quantitatively estimate the true activity concentration in the physical phantoms. Results show variations of emission recovery between 13.8% and 104.5% depending on sphere volume and number of OSEM-3D updates. After correction for the emission recovery errors and cross calibration of the imaging system the errors in absolute quantitation using the physical sphere phantom are between +0.01±0.61% for the largest (16 ml) and −5.87±1.00% for the smallest (0.5 ml) sphere. As a conclusion, the emission recovery varies over a wide range and is highly dependent on imaging parameters when using OSEM-3D reconstruction. Accurate quantitation in phantoms is possible given that errors at the specific imaging operation point can be estimated. In a clinical setup this is a nontrivial task, and perhaps too cumbersome for routine clinical use.
Starting Page	4106
Ending Page	4111
File Size	4127959
Page Count	6
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774185
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Error analysis Attenuation Scattering Energy resolution Image reconstruction Imaging phantoms Calibration Error correction Estimation error Collimators
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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