NDLI: PET/CT alignment for small animal scanners based on capillary detection

Content Provider	IEEE Xplore Digital Library
Author	Rodriguez-Ruano, Alexia Pascau, Javier Chamorro, Judit Sisniega, Alejandro Garcia-Vazquez, Veronica Udias, Angel Vaquero, Juan Jose Desco, Manuel
Copyright Year	2008
Description	Author affiliation: Departamento de Estadística e Investigación Operativa, Universidad Rey Juan Carlos, 28943 Fuenlabrada, Spain (Udias, Angel) \|\| Unidad de Medicina y Cirugía Experimental Hospital General Universitario Gregorio Marañón, Madrid, Spain (Rodriguez-Ruano, Alexia; Pascau, Javier; Chamorro, Judit; Sisniega, Alejandro; Garcia-Vazquez, Veronica; Vaquero, Juan Jose; Desco, Manuel)
Abstract	Small animal PET/CT devices provide anatomical and molecular imaging at the same time, enabling the joint visualization and analysis of both modalities. An accurate PET/CT alignment is required to correctly interpret these studies. A proper calibration procedure is essential for small animal imaging, since resolution is much higher than in human devices. This work presents an alignment phantom and a method that enable a reliable and replicable measurement of the geometrical relationship between PET and CT modules. The phantom can be built with laboratory materials, and is used to estimate the rigid spatial transformation that aligns both modalities. It consists of three glass capillaries located in non-coplanar triangular geometry and filled with FDG, so they are easily identified in both modalities. The method is based on automatic line detection and localization of the corresponding points between the lines on both modalities, which allows calculating the rigid alignment parameters. Different geometric configurations of the phantom (i.e. different angles and distances between capillaries) were tested to assess the repeatability of the calculations. To measure the alignment precision achieved, we attached two additional sodium point sources to the phantom, which were neglected in the registration process. Our results show that the accuracy of the alignment estimation, measured as average misalignment of the Na sources, is below half the PET resolution. The alternative settings for the phantom layout did not affect this result, indicating the low dependency of the alignment calculated with the actual phantom layout. Our approach allows measuring the PET/CT transformation parameters using an in-house built phantom and with low computational effort and high accuracy, demonstrating that the proposed phantom is suitable for alignment calibration of dual modality systems on a real environment.
Starting Page	3832
Ending Page	3835
File Size	5242109
Page Count	4
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774117
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Animals Imaging phantoms Computed tomography Calibration Molecular imaging Joints Visualization Image analysis High-resolution imaging
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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