NDLI: Real-time X-ray 2-D and 3-D micro-imaging of living animals with Medipix2 single photon counting detector

Content Provider	IEEE Xplore Digital Library
Author	Frallicciardi, Paola M. Dammer, Jiri Weyda, Frantisek Jakubek, Jan Vavrik, Daniel Pospisil, Stanislav
Copyright Year	2008
Description	Author affiliation: Institute of Experimental and Applied Physics, Czech Technical University in Prague, Horska 3a/22, CZ-12800, Czech Republic (Dammer, Jiri; Jakubek, Jan; Vavrik, Daniel; Pospisil, Stanislav) \|\| Istituto Nazionale di Fisica Nucleare (INFN), Italy (Frallicciardi, Paola M.) \|\| Biology Centre of the Academy of Sciences of the Czech Republic v. v. i., Institute of Entomology and Faculty of Science, University of South Bohemia, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic (Weyda, Frantisek)
Abstract	In this work we present the study of applicability of a desktop size radiographic/tomographic X-ray system for real-time microscopy and micro-tomography in the fields of biology, entomology, botanic and medical imaging. The apparatus is made up of the single photon counting pixel silicon detector, Medipix2 (matrix of 256×256 square pixels of 55 μm pitch) and a microfocus X-ray tube with a minimum spot size of 5 μm and a tungsten anode. The system has been used for observations of time-dependent processes inside living and still biological and organic samples. Excellent contrast and spatial resolution (micrometer scale) were obtained as a combination of a) low photon energy (40 kVp X-ray tube voltage), b) single photon counting operation, witch avoids integration of dark current c) energy discrimination in each pixel, allowing noise rejection and providing high SNR, d) high effective dynamic range for long exposures, which allows for high signal with high SNR, e) implementation of an original procedure for the energy response calibration of each pixel of the detector matrix, f) high speed read-out hardware and software, which opens the possibility to perform real-time studies of biological processes permitting, e.g., observation of morphological changes, mutations or metamorphosis of living animals and plants. Static and dynamic images of a parasite life cycle from the larva stage to pupa stage are presented here, as well as an in vivo computed tomography of the parasite living inside its host.
Starting Page	4760
Ending Page	4766
File Size	14398051
Page Count	7
File Format	PDF
ISBN	9781424427147
ISSN	10957863
DOI	10.1109/NSSMIC.2008.4774307
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-10-19
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals X-ray detection X-ray detectors X-ray imaging Signal to noise ratio Radiography Tomography Real time systems Microscopy Biomedical imaging
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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