NDLI: Prevent Reconstruction of Ischemic Myocardium with Autologous Stem Cells Transfected by AKT Gene

Content Provider	IEEE Xplore Digital Library
Author	Yu Yunsheng Shen Zhenya Ye Wenxue Chen Yihuan Lao Weijie Tao Li
Copyright Year	2010
Abstract	Abstract Background: To test the hypothesis that AKT1-engineered Mesenchymal stem cells (MSCs) are more resistant to apoptosis than MSCs and can enhance cardiac repair after transplantation into the ischemia swine heart. Methods： All ischemia swines were divided into four groups: the control group(A), the DMEM group（B）, the MSCs group(C), and the AKT-transfected group(D). The MSCs were transfected with the AKT1 gene, after which autologous BrdU labeled stem cells was injected into LAD of the infarct heart by transcatheter in the group C and D. In the group B, DMEM was injected in the same distraction by the same approach. In group A, there is no other injection after occluding the LAD. Then 4 weeks later, the cardiac function and regional perfusion measurements were repeated by MRI and Echocardiography, and the histological characteristics of the hearts were also studied to assess MSCs engraftment. VEGF, TGF-β1, Connecxin-43, BrdU and VWF were tested . Results: The cardiac function was significantly improved after the cells implantation, and the implanted MSCs prevented the infarct region from thinning and expanding, improved contraction and increased perfusion in all groups relative to the control group. Moreover, the improvement was even markedly greater in Group D. Conclusion The MSCs engraftment in host myocardium might improve the cardiac function by attenuating the contractile dysfunction and pathologic thinning in this model of left ventricular wall infarction.
Starting Page	1
Ending Page	7
File Size	381060
Page Count	7
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5517090
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart Ischemic pain Magnetic resonance imaging Cardiac disease Stem cells Myocardium Performance analysis Cardiology Arteries Testing
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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