NDLI: Research on Specroscopy of Cu(II) on Peroxynitrite Nitrifying Fibrinogen

Content Provider	IEEE Xplore Digital Library
Author	Yunjing Luo Qi Zhu Shuang Cui Dawei Zheng Jiangnan Suo
Copyright Year	2010
Abstract	Many studies have showed that peroxynitrite-mediated injury on fibrinogen has some relations with Thrombotic diseases. However there are few reports about structural changes of nitrified fibrinogen when metallic ions exist in this reaction. In this study, we use methods of FTIR-ATR spectra and 3D Fluorescence spectra to study the structural changes on fibrinogen after nitration and oxidation damages caused by ONOO- with Cu(Π) exist. Our results showed that Cu(Π) enhance the production of 3-nitrotyrosine in proteins, The FTIR spectra indicated that the α-helix in fibrinogen reacted with ONOO- by adding Cu(Π) decreases from 38.03 % to 28.5 %, whereas β-sheet increases from 29.89% to 43.99 %. Consequently, Cu(Π) could promote Fg nitration with its concentration dependence.
Starting Page	1
Ending Page	4
File Size	1160820
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5515063
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Spectroscopy Parkinson's disease Fluorescence Amino acids Educational institutions Oxidation Infrared spectra Injuries Biomedical engineering
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Research on Specroscopy of Cu(II) on Peroxynitrite Nitrifying Fibrinogen