NDLI: Acellular Tissue Engineering Scaffolds for Vocal Fold Regeneration

Content Provider	IEEE Xplore Digital Library
Author	Chan, R.W.
Copyright Year	2010
Abstract	A variety of xenogeneic and allogeneic extracellular matrix (ECM) scaffolds have been promising in various tissue engineering applications, such as the porcine small intestinal submucosa. Yet no particular scaffolds have been optimal for vocal fold regeneration. The decellularized human umbilical vein (HUV) is a novel allogeneic scaffold that has shown some promise for cardiovascular tissue engineering. This study examines the potential of the HUV as an acellular scaffold for engineering the vocal fold lamina propria, in order to develop an implantable tissue substitute that can promote a natural ECM remodeling response. A novel saline-based decellularization protocol developed in our laboratory was used to fabricate a three-dimensional (3-D), biodegradable, acellular scaffold from native HUV tissue. Histological examination and scanning electron microscopy indicated that native cells in the HUV were removed with a fine 3-D structure of proteins and proteoglycans well preserved. Primary human vocal fold fibroblasts were cultivated on the abluminal surface of the acellular scaffold in vitro. Significant proliferation and infiltration of the fibroblasts in the scaffold were observed. These findings supported the biocompatibility of the HUV scaffold, and its promise for vocal fold reconstruction and regeneration.
Starting Page	1
Ending Page	2
File Size	168583
Page Count	2
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5517382
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Intestines Protocols Regeneration engineering Veins Tissue engineering Humans Electrochemical machining Fibroblasts Cardiology Extracellular
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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