NDLI: Oxidative Damage of Decabromodiphenyl Ether (BDE209) on the Hepatic Cells of Rat in vitro

Content Provider	IEEE Xplore Digital Library
Author	Yao Wen-hao Jiang Ming-di Hu Qin-qin Li Ren Yang Xu
Copyright Year	2010
Abstract	Owing to its good flame-retardant effect, polybrominated diphenyl ethers (PBDEs) were widely added to electronic, electrical appliances, as well as textiles and chemical products. Decabromodiphenyl Ether (BDE-209) is one class of PBDEs which was most demanded in international market. To illustrate the possible function of BDE-209 on rat liver, hepatic cells were expose to BDE-209 with different concentrations (1, 2, 4, 8, 16 mg•L-1) in vitro, the contents of malondialdehyde (MDA) and the levels of DNA-protein crosslinks (DPC) were investigated. The results indicated that: with the BDE-209 exposure concentrations increased, MDA content and DPC coefficient increased gradually, showed almost the same trend. Significant difference was observed in both MDA content and DPC coefficient in the 4 ，8 and 16 mg•L-1 (P<0.05) groups compared to the control group, while extremely significant difference was observed in the 16 mg•L-1 groups (P<0.01). Moreover, MDA content has a good dose-response relationship with the BDE-209 exposure concentrations(R=0.995, P<0.05), so does DPC (R=0.996, P<0.05). The results suggested that the BDE-209 exposure can cause oxidative stress and genetic toxicity to rat liver, demonstrating hepatotoxic effect as well as genetic effect to the body.
Starting Page	1
Ending Page	4
File Size	309660
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5515242
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pollution Liver Chemical products Flame retardants Genetics Polymers In vitro Consumer electronics Stress Textiles
Content Type	Text
Resource Type	Article

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