NDLI: Gene Expression Data Displaying Up-Regulation and Down-Regulation of Amino Acid Nutritional Metabolic Modules

Content Provider	IEEE Xplore Digital Library
Author	Jing Li
Copyright Year	2010
Abstract	Raw gene expression data and amino acid metabolic pathway of Saccharomyces cerevisiae were excavated by SMD (Stanford Microarray Database) and KEGG (Kyoto Encyclopedia of Genes and Genomes), respectively. The methionine and cysteine nutritional metabolic modules were selected and analyzed, expecting to establish the relationship between the modules, and find out the important genes, which made predominant contribution for the up-regulation and down-regulation of modules, to identify the differences and synergies in expression levels. The results show that four common genes exist between these two modules, comprising YAL012W (4.4.1.1), YFR055W (4.4.1.8), YJR130C (2.5.1.48) and YLR303W (2.5.1.49). For methionine modules, the five important genes were YAL012W (4.4.1.1), YDR502C (2.5.1.6), YER043C (3.3.1.1), YGR155W (4.2.1.22) and YLR303W (2.5.1.49), playing a decisive role in the gross of gene expression, while for cysteine modules, those are YAL012W (4.4.1.1), YLR303W (2.5.1.49), YNL247W (6.1.1.16) and YCL064C (4.3.1.17). Maybe the cooperative up-regulation relations exist between these two modules, while because of different gene numbers in modules, the synergies between gene expression gross values were not distinct. But certain crucial metabolite can be accumulated by controlling the important genes in the metabolic process.
Starting Page	1
Ending Page	4
File Size	438904
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5517806
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Databases Laboratories Food technology Genomics Amino acids Biochemistry Organisms Gene expression Bioinformatics
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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