NDLI: Finding Finer Functions of Cancer Proteins and Rebuilding Cancer-Associated Functional Sub-Networks

Content Provider	IEEE Xplore Digital Library
Author	Yanhui Li Wencai Ma Zheng Guo Chunfang Peng Jing Wang Xue Gong Da Yang Qing Liu Yunyan Gu Min Zhang Jing Zhu Chenguang Wang
Copyright Year	2010
Abstract	The functional knowledge of cancer proteins and cancer pathways is currently limited and not detailed enough, remaining as a major hurdle to cancer studies. Particularly, many cancer proteins are only annotated to high-level general GO categories. Here, we apply an efficient algorithm, by constructing function-specific protein-protein interaction sub-networks, to find finer functions of the cancer proteins compiled in Cancer Gene Census database. By exploiting their previously known functions, 193 cancer proteins are predicted to finer functional categories, with F score higher than 0.6. Furthermore, because cancer proteins contribute to carcinogenesis through alterations of some essential cellular functions, discovering additional proteins involved in such functions is also of importance for uncovering the mechanisms of cancer. To approximate cancer functions, 37 specific functions significantly enriched with known cancer proteins are selected. With F score higher than 0.6, 221 proteins are predicted to these cancer functions, improving the connection of the function-specific interaction sub-networks and thus delineating cancer functions more integrally and clearly.
Starting Page	1
Ending Page	4
File Size	1619437
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5515039
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protein engineering Databases Laboratories Biological processes Prediction algorithms Bioinformatics Joining processes Biological information theory Cancer Immune system
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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