NDLI: Preparation and Release Dynamic of Ibuprofen Polymeric Prodrug with Glucose Pendant

Content Provider	IEEE Xplore Digital Library
Author	Cheng-Yao Wu Jing Quan Jian-Gang Xie Li-Min Zhu Branford-White, C.J.
Copyright Year	2010
Abstract	A kind of polymeric prodrug of ibuprofen with glucose pendant was prepared through chemo-enzymatic method. The obtained polymeric prodrug was characterized by FT-IR, NMR and GPC. The molecular weight of the polymeric prodrug reached 2.126 × 104. Furthermore, the in vitro release behaviors of ibuprofen (raw drug) and the polymeric prodrug were investigated in pH 7.4 buffer solution at 37 oC. It was suggested that low-molecular-weight ibuprofen was fast released and the cumulative release amount was almost 100% after 3 h, while only about 4 % of parent drug was released from polymeric prodrug in the same time. The continuous release investigation showed that the cumulative parent drug amount released from the polymeric prodrug reached 32% after 10 days. Compared to the raw drug, the polymeric prodrug of ibuprofen with glucose pendant had a better effect of prolonged release, and the release of ibuprofen from polymeric prodrug exhibited first order kinetic equation.
Starting Page	1
Ending Page	4
File Size	255485
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5515768
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Chemical analysis Nuclear magnetic resonance Kinetic theory Polymers In vitro Sugar Chemical technology Equations Methanol
Content Type	Text
Resource Type	Article

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