NDLI: Acute Toxicity of Different Sized ZnO Nanoparticles in Mice after Intratracheal Administration

Content Provider	IEEE Xplore Digital Library
Author	Wenhua Song Jinhua Zhang Jinyang Zhang
Copyright Year	2010
Abstract	Acute toxicity of different sized (10, 30 and 100nm) ZnO particles was investigated by intratracheal injection at the dose of 0.05 and 0.5g/kg body weight. The results of biochemical parameters assay, pathological examination and zinc accumulation showed main target organs for ZnO particles are demonstrated as lung, spleen, pancreas, bone and liver after exposure by intratracheal injection. But the toxic effects between different sized and dose ZnO particles are a little different. The toxicity of ZnO nanoparticles exhibited a dose-effect relationship. At low dose, three sized ZnO particles induce slight damage, and 10nm ZnO particles lead to relatively serious lung and liver damage. At high dose, 30nm ZnO particles result in worse lung, liver and pancreas injury. Furthermore, ZnO nanoparticles led to oxide stress, which may be an important reason for injury induced by ZnO particles.
Starting Page	1
Ending Page	4
File Size	2979728
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5515207
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanoparticles Pathology Lungs Liver Zinc oxide Bones Mice Pancreas Injuries Stress
Content Type	Text
Resource Type	Article

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