NDLI: Strand Symmetry: Characteristics and Origins

Content Provider	IEEE Xplore Digital Library
Author	Shang-Hong Zhang Ya-Zhi Huang
Copyright Year	2010
Abstract	In order to reveal the genetic information contained in the primordial genome (defined as the most primitive nucleic acid genome for Earth's life), one of the possible means is to search for primitive traits or relics remained in modern genomes. As the shorter is a sequence, the less probable it would be modified during genome evolution. For that reason, some characteristics of very short nucleotide sequences would have considerable chances to persist during billions of years of evolution. Consequently, conservation of certain genomic features of mononucleotides, dinucleotides, and higher-order oligonucleotides across various genomes may exist; some, if not all, of these features would be relics of the primordial genome. Based on this assumption, we analyzed the pattern of frequencies of mononucleotides, dinucleotides, and higher-order oligonucleotides of the whole-genome sequences from 458 species (including archaea, bacteria, and eukaryotes) to study the phenomenon of strand symmetry. The results show that strand symmetry is a ubiquitous and explicit phenomenon. Considering and evaluating various views on the origins of the phenomenon of strand symmetry, we propose a new hypothesis about its origin as well as about the constitution of early genomes. We conclude that the phenomenon of strand symmetry would be the original feature and relic of the primordial genome.
Starting Page	1
Ending Page	4
File Size	199738
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5517388
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sequences Microorganisms Evolution (biology) Genomics DNA Archaea Frequency Genetics Bioinformatics Pattern analysis
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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