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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yu-bin Ji Miao Yu Lei Yu Wen Yang Ying-jie Yang |
| Copyright Year | 2010 |
| Abstract | This article studied whether genetic toxicity of toluene diisocyanate was reversible. Kunming mice were exposed to TDI by respiratory tract for 14 days in 1/8LC50, 1/4LC50 and 1/2 LC50 dosage and then were feed normally for 14 days. The chromosomal aberrations and the content of RNA & DNA were detected by optical microscope and laser scanning confocal microscope. In 1/4LC50 and 1/2 LC50 group, chromosome aberration rate and the RNA / DNA ratio of TDI were higher than control group significantly (P<0.01). In addition there was no significant difference between 1/4LC50 and 1/2 LC50 (p> 0.05). The results showed that the damage of TDI on chromosomes and DNA was repairable, but can not be repaired completely. |
| Starting Page | 1 |
| Ending Page | 4 |
| File Size | 331168 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424447121 |
| ISSN | 21517622 |
| DOI | 10.1109/ICBBE.2010.5515186 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-06-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Sealing materials Optical microscopy Biomedical optical imaging RNA DNA Cells (biology) Fluorescence Genetics Mice Biological cells |
| Content Type | Text |
| Resource Type | Article |
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