NDLI: Simulation and Analysis of the Network Model of the Quorum Sensing Process during Biofilm Creation

Content Provider	IEEE Xplore Digital Library
Author	Ruixuan Zhao Mingzhi Mao
Copyright Year	2010
Abstract	System biology is one of the leading edge cross-subjects which requires the cooperation between computer science and biological science. Abstracting complex life phenomenon, like metabolic or transcription regulation pathway, into networks to simulate these processes is one of the hotspots in System biological research. In this paper, we construct a network to simulate one of the most concerned areas in micro-biological research, the formation of the biofilm structure. The research concerning the biofilm is critical as most pathogen micro-organism form this structure to resist most antibiotics. Specifically, we focused on the Quorum sensing pathway which is a microbial cell-cell communication process influencing the biofilm formation to a large extent. By deleting some of the components locating at different topological position within the network and analyzing the variation of topological parameters of the resulting networks, we discovered that the deletion of lasR or AHL1 can undermine the whole network to a great extent. Therefore, it can be predicted that the most crucial elements who may control the whole process is the lasR and AHL1. These predictions may provide valuable information for the drug-target design project and contribute to the control of the diseases brought by pathological micro-organism.
Starting Page	1
Ending Page	4
File Size	730166
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5514790
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computer science Analytical models Pathogens Biological system modeling Computational modeling Antibiotics Systems biology Process control Resists Diseases
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Computer analysis of biological processes

Analysis of computer simulation and virtual biology modeling

Quantum Gate Circuit Model of Signal Integration in Bacterial Quorum Sensing

Multi-Level Modeling and Simulation in Systems Biology -- Promises and Challenges

Design methodologies for securing cyber-physical systems

Controllability Analysis of Biosystems Based on Piecewise-Affine Systems Approach

Simulation of Intelligent Computational Models in Biological Systems

Biological Network Simulation Using Holonic Multiagent Systems

Computer virus propagation modeling and simulation

Simulation and Analysis of the Network Model of the Quorum Sensing Process during Biofilm Creation

Similar Documents

Computer analysis of biological processes

Analysis of computer simulation and virtual biology modeling

Quantum Gate Circuit Model of Signal Integration in Bacterial Quorum Sensing

Multi-Level Modeling and Simulation in Systems Biology -- Promises and Challenges

Design methodologies for securing cyber-physical systems

Controllability Analysis of Biosystems Based on Piecewise-Affine Systems Approach

Simulation of Intelligent Computational Models in Biological Systems

Biological Network Simulation Using Holonic Multiagent Systems

Computer virus propagation modeling and simulation

Simulation and Analysis of the Network Model of the Quorum Sensing Process during Biofilm Creation