NDLI: Use Human Breast Cancer Cells to Examine Change of Estrogenicity in Drinking Water Treatment Process

Content Provider	IEEE Xplore Digital Library
Author	Guangming Zhang Lang Lang Yu Li
Copyright Year	2010
Abstract	Endocrine disruptors (EDCs) have caused great concerns for the safety of water environment and drinking water in recent years. This paper uses lab-cultured human breast cancer cells (MCF-7) to examine the changes of water estrogenicity during the drinking water treatment process and uses chemical analysis as supplementary information. The results showed that MCF-7 were extremely sensitive to the aqueous estrogenicity; cell proliferation by 17- Estradio (E2) was observed at concentration as low as 10-14 mol/l. Overdose might cause poisoning of cell, which led to the cell decrease instead of proliferation. The source water of Songhua River showed significant estrogenicity, which was effectively controlled by regular drinking water treatment process. Coagulation-sedimentation was very effective in decreasing the water estrogenicity and almost eliminated the proliferation effect of the source water, the filtration step, on the other hand, increased the water estrogenicity by almost 10%; the final disinfection then reduced the estrogenicity to the normal level. The overall effect was that the finished water was safe in terms of estrogenicity though the source water was unsafe.
Starting Page	1
Ending Page	3
File Size	249533
Page Count	3
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5516235
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Chemical analysis Endocrine system Humans Breast cancer Biochemistry Water pollution Safety Water resources Chemical technology Testing
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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