NDLI: Oxidative Stress-Mediated Pro-Inflammatory Responses in Lung Epithelial Cells Exposed to Multi-Walled Carbon Nanotubes

Content Provider	IEEE Xplore Digital Library
Author	Min Han Shefang Ye Wen Wen Qiqing Zhang
Copyright Year	2010
Abstract	Reactive oxygen species (ROS) and activation of redox-sensitive transcription factors such as nuclear factor (NF)-kB have been implicated in pro-inflammatory responses induced by nanoparticles. However, there is still only little knowledge about the pro-inflammatory responses induced by multi-walled carbon nanotubes (MWCNTs). The objective of the present study was to compare the ability of MWCNTs and carbon black (CB) nanoparticles to induce secretion of pro-inflammatory cytokines and to explore possible mechanisms in A549 lung epithelial cells. Exposure of A549 cells to MWCNTs, but not to CB, resulted in a significant increase in interleukin-8 (IL-8) release and gene expression. MWCNTs stimulated NF-kB DNA binding activity, nuclear translocation of the p65 subunit of NF-kB, IkBa phosphorylation, and ROS generation in A549 cells. MWCNTs-induced IL-8 gene expression and NF-kB activation were abrogated in the presence of ROS scavengers. These results suggest that MWCNTs are able to induce pro-inflammatory responses and NF-kB activation in A549 cells mediated by ROS generation.
Starting Page	1
Ending Page	4
File Size	653673
Page Count	4
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5516569
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanoparticles Proteins Lungs Carbon nanotubes Nuclear power generation Gene expression Chemical elements Nanobioscience Biomedical engineering Biological materials
Content Type	Text
Resource Type	Article

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