NDLI: Prevent Mammary Cancer Cell Adhesion in Microvasculature in vivo by Mild Hypothermia

Content Provider	IEEE Xplore Digital Library
Author	Lv, Yonggang Hao, Xiaoying Yang, Li Lin, Manping
Copyright Year	2010
Abstract	To investigate the effect of mild hypothermia on the mammary cancer cell adhesion to intact microvessels wall, video microscopy was used to measure the adhesion rates of mouse normal mammary epithelial cells (Nmumg) and wild type (WT) in the post-capillary venules of rat mesentery in vivo. Individual post-capillary venule was cannulated and perfused with cells (~4 million/ml) at a rate of ~1 mm/s, 1) under normothermia, 2) after pretreatment of the microvessel with mild hypothermia. Our results showed that in ~60min, a) normal cells adhere poorly to microvessels in vivo while WT adhere to a much larger extent as compared to normal cells; b) in 60 min, mild hypothermia treatment decreased the number of adherent WT tumor cells from 9.9 (±±1.0 SE, n=7) to 6.6 (±±0.8 SE, n=6) cells/(5000 µm² vessel plane section). These results suggest that mild hypothermia such as winter swimming may be a potential tool for preventing cancer among people with pre-malignant tumors or who are otherwise at high risk for cancer. This study may shed new light on the relative contributions of cancer prevention by thermophysical method using mild hypothermia.
Starting Page	1
Ending Page	3
File Size	392202
Page Count	3
File Format	PDF
ISBN	9781424447121
ISSN	21517622
DOI	10.1109/ICBBE.2010.5515903
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-18
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vivo Adhesives Microscopy Mice Breast cancer Tumors
Content Type	Text
Resource Type	Article

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