NDLI: Unnatural killer cells: TRAIL-coated leukocytes that kill cancer cells in the circulation

Content Provider	IEEE Xplore Digital Library
Author	Mitchell, M.J. Wayne, E.C. Rana, K. Schaffer, C.B. King, M.R.
Copyright Year	2014
Description	Author affiliation: Dept. of Biomed. Eng., Cornell Univ., Ithaca, NY, USA (Mitchell, M.J.; Wayne, E.C.; Rana, K.; Schaffer, C.B.; King, M.R.)
Abstract	Metastasis through the bloodstream contributes to poor prognosis in many types of cancer. Mounting evidence implicates selectin-based adhesive interactions between cancer cells and the blood vessel wall as facilitating this process, in a manner similar to leukocyte trafficking during inflammation. Here, we describe a unique approach to target and kill colon and prostate cancer cells in the blood that causes circulating leukocytes to present the cancer-specific apoptosis ligand TRAIL on their surface along with E-selectin adhesion receptor. This approach, demonstrated in vitro with human blood and also in mice, mimics the cytotoxic activity of natural killer cells and increases the surface area available for delivery of the receptor-mediated signal. The resulting “unnatural killer cells” hold promise as an effective means to neutralize circulating tumor cells that enter blood with the potential to form new metastases.
Starting Page	1
Ending Page	2
File Size	2584346
Page Count	2
File Format	PDF
ISBN	9781479937288
DOI	10.1109/NEBEC.2014.6972880
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-04-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cancer Cells (biology) Blood Mice Tumors Fluorescence Adhesives cell adhesion drug delivery cancer therapy
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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TRAIL-coated leukocytes that kill cancer cells in the circulation

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