NDLI: Microfluidic cardiac circulation model (µCCM) for functional cardiomyocyte studies

Content Provider	IEEE Xplore Digital Library
Author	Nguyen, M.-D. Giridharan, G. Prabhu, S.D. Sethu, P.
Copyright Year	2009
Description	Author affiliation: Department of Bioengineering, 2210 S. Brook St., BRB 357, University of Louisville, Louisville, KY 40208 (Nguyen, M.-D.; Giridharan, G.; Sethu, P.) \|\| Division of Cardiology, School of Medicine, University of Louisville (Prabhu, S.D.)
Abstract	Physiological heart development and cardiac function rely on the response of cardiomyocytes to mechanical stress signals during hemodynamic loading and unloading. These stresses manifest themselves via changes in cell structure, contractile function and gene expression. Disruption of this well balanced stress-sensing machinery due to various pathological conditions results in contractile dysfunction, cardiac remodeling and heart failure. In order to study signaling mechanisms involved in the pathogenesis of various manifestations of Cardiovascular Disease (CVD), there is a need for physiologically relevant in-vitro models. To accomplish this goal, we have developed a Microfluidic Cardiac Circulation Model (µCCM) that integrates mechanically loaded cardiomyocytes with fluid flow and a circulation network.
Starting Page	1060
Ending Page	1063
File Size	470364
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334997
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microfluidics Cardiology Heart Stress Hemodynamics Gene expression Machinery Pathology Pathogens Cardiovascular diseases
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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