NDLI: LyP-1 ultrasonic microbubbles targeting to cancer cell as tumor bio-acoustics markers or drug carriers: Targeting efficiency evaluation in, microfluidic channels

Content Provider	IEEE Xplore Digital Library
Author	Xiang Li Qiaofeng Jin Tan Chen Baoyue Zhang Rongqin Zheng Zhanhui Wang Hairong Zheng
Copyright Year	2009
Description	Author affiliation: Paul Lauterbur Center for Biomedical imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (Xiang Li; Qiaofeng Jin; Hairong Zheng) \|\| Third Affiliated Hospital of Sun Yat-sen University (Rongqin Zheng) \|\| CAS/CUHK Research Centre for Biosensors and Medical Devices, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy (Tan Chen; Baoyue Zhang; Zhanhui Wang)
Abstract	Using ultrasonic contrast microbubbles as acoustic biomarkers and drug carrier vehicles by conjugating tumor specific antibody to microbubbles has shown great potential in ultrasonic tumor molecular imaging or drug-delivery and therapy. Microbubble probe targeting efficiency is one of the major challenges. In this study, we developed a novel method to evaluate the targeting capability and efficiency of microbubbles to cells, and more specifically, microbubbles binding LyP-1 (a cyclic nonapeptide acid peptide) target to cancer cell within a microfluidic system. The micro cell sieves within the microfludic channels could trap the tumor cells and enhance the microbubble's interaction with the cell. Assisted with the controllable fluid shear stress, the microbubble's targeting to the cell and the corresponding affinity efficiency could be quantitatively evaluated under a florescent microscope. The system provides a useful low-cost high efficient in vitro platform for studying microbubble-cell interaction for ultrasonic tumor molecular imaging or drug-delivery and therapy.
Starting Page	463
Ending Page	466
File Size	1140983
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334473
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cancer Neoplasms Drugs Microfluidics Molecular imaging Medical treatment Biomarkers Vehicles Probes Peptides drug delivery Targeted Microbubbles ultrasound molecular image
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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