NDLI: A computer study of the effects of branching dimension on safety factor distribution and propagation in a cardiac conduction network

Content Provider	IEEE Xplore Digital Library
Author	Zhao, J. Smaill, B.H. Pullan, A.J.
Copyright Year	2009
Description	Author affiliation: Bioengineering Institute, The University of Auckland, 1142, New Zealand (Zhao, J.; Smaill, B.H.; Pullan, A.J.)
Abstract	Branching conduction networks are responsible for coordinated distribution of activation throughout the heart, but the effects of branching geometry on the efficiency of distribution and the safety of propagation remain unclear. We have developed a simplified computer model to investigate this issue in a systemic fashion. A simplified 2D model that reproduces key features of the right atrial pectinate muscle network has been developed. This consists of a large main strand that gives rise to regularly spaced perpendicular branches. Safety factor (SF) and activation time (AT) within the network are estimated for a range of different branch dimensions. The SF is reduced as branch dimension is increased due to the larger current load and is least at the proximal edge of the junction between the main strand and branches. On the other hand, activation efficiency depends on appropriate balance between the load imposed by branching and source which they subsequently provide. With repeated stimulation at progressively decreasing coupling intervals, the SF and conduction fall within the network, but the locations of block varied with branching dimension, again reflecting spatial variation in the balance between current source and current load. We hypothesize that the observed geometry of the branching network optimizes distribution efficiency and propagation safety.
Starting Page	3278
Ending Page	3281
File Size	958743
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5333514
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computer networks Distributed computing Safety Muscles USA Councils Heart Computational geometry Frequency Robustness Propagation delay
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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