NDLI: One-dimensional modelling of pulse wave propagation in human airway bifurcations in space

Content Provider	IEEE Xplore Digital Library
Author	Clavica, F. Alastruey, J. Sherwin, S.J. Khir, A.W.
Copyright Year	2009
Description	Author affiliation: Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK (Clavica, F.; Khir, A.W.) \|\| Department of Bioengineering, Imperial College London, South Kensington Campus, SW7 2AZ London, UK (Alastruey, J.) \|\| Department of Aeronautics, Imperial College London, South Kensington Campus, SW7 2AZ London, UK (Sherwin, S.J.)
Abstract	Airflow in the respiratory system is complicated as it goes through various regions with different geometries and mechanical properties. Three-dimensional (3-D) simulations are typically limited to local areas of the system because of their high computational cost. On the other hand, the one-dimensional (1-D) equations of flow in compliant tubes offer a good compromise between accuracy and computational cost when a global assessment of airflow in the system is required. The aim of the current study is to apply the 1-D formulation in space and time variables to study the propagation of a pulse wave in human airways; first in a simple system composed of just one bifurcation, trachea-main bronchi, according to the symmetrical Weibel model. Then extending the system to include a further generation, the bronchi branches. Pulse waveforms carry information about the functionality and morphology of the respiratory system and the 1-D modelling, in terms of space and time variables, represents an innovative approach for respiratory response interpretation. 1-D modelling in space-time variables has been extensively applied to simulate blood pressure and flow in the cardiovascular system. This work represents the first attempt to apply this formulation to study pulse waveforms in the human bronchial tree.
Starting Page	5482
Ending Page	5485
File Size	531972
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334564
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Humans Bifurcation Respiratory system Computational efficiency Geometry Mechanical factors Computational modeling Equations Morphology Blood pressure
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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