NDLI: Effects of hypocalcemia on electrical restitution and ventricular fibrillation

Content Provider	IEEE Xplore Digital Library
Author	Ricco, M.L. Fei Hua Lomonte, D.J. Venator, K.R. Cerda-Gonzalez, S. Gilmour, R.F.
Copyright Year	2009
Description	Author affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853 USA (Ricco, M.L.; Gilmour, R.F.) \|\| New York Presbyterian Hospital, New York, NY USA (Lomonte, D.J.) \|\| Pfizer, Inc., Boston, MA USA (Fei Hua) \|\| Department of Clinical Sciences, Cornell University, Ithaca, NY 14853 USA (Cerda-Gonzalez, S.) \|\| Nestle Purina, Inc., St. Louis, MO USA (Venator, K.R.)
Abstract	We have shown previously that verapamil reduces the slope of the action potential duration (APD) restitution relation, suppresses APD alternans and converts ventricular fibrillation (VF) into a periodic rhythm. To determine whether these effects result primarily from reduction of the APD restitution slope, as opposed to alteration of calcium dynamics unrelated to restitution, we tested the effects of hypocalcemia ([CaCl2] = 3D 31-125 µM) in canine ventricle. At normal [CaCl2] (2.0 mM), the slope of the APD restitution relation was > 1, APD alternans occurred during rapid pacing and VF was inducible. During hypocalcemia the slope of the restitution relation remained > 1 and the magnitude of APD alternans was unchanged. VF still was inducible and the mean cycle length and the variance of the FFT spectra during VF were not altered significantly. These results suggest that reduction of APD restitution slope, rather than blockade of ICa per se, is responsible for the antifibrillatory effects of verapamil in this model of pacing-induced VF, lending further support to the idea that APD restitution kinetics is a key determinant of VF.
Starting Page	4182
Ending Page	4185
File Size	610526
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5333928
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fibrillation Calcium Rhythm Independent component analysis Spirals Heart Velocity measurement Animals Electrodes USA Councils
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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