NDLI: Cardiac action potential wavefront tracking using optical mapping

Content Provider	IEEE Xplore Digital Library
Author	Ashraf, A. Nygren, A.
Copyright Year	2009
Description	Author affiliation: Department of Physiology and Biophysics at the University of Calgary, Calgary, AB, Canada (Nygren, A.) \|\| Electrical Engineering BMES undergraduate from the University of Calgary, Calgary, AB, Canada (Ashraf, A.)
Abstract	A wealth of knowledge is available about the effect of diabetes on the heart but very little has been done to quantify the conduction velocity of the diabetic heart. This study intends to develop a technique for tracking the cardiac wavefront across the heart in order to achieve the total activation time as well as the conduction velocity of the heart at any point during its activation, to compare the newly determined activation times with previously determined activation times, and to also compute the average conduction velocity of the heart from diabetic and control rats. The technique developed for tracking the action potential wavefront across the heart extracts the wavefront and provides the activation time as well as the conduction velocity – both instantaneous and average – successfully. The method reproduces previously measured activation times well, with a correlation of $R^{2}$ = 3D 0.875, which suggests that this technique is reliable and that its determination of conduction velocity will allow for the examination of healthy and diseased hearts using a new criterion. In addition, the method for determining the conduction velocity of the heart allows direct comparison of the baseline conduction velocity in control and diabetic hearts. The results of this comparison indicated that conduction velocity in the diabetic hearts is slower (0.47 ± 0.02 m/s) than in control hearts (0.55 ± 0.02 m/s) (p = 3D 0.001).
Starting Page	1766
Ending Page	1769
File Size	400513
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5333404
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart Diabetes Optical propagation Optical imaging Time measurement Voltage Spatial resolution Velocity control Electric variables measurement Force measurement
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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