NDLI: Therapeutic ultrasound angioplasty: The risk of arterial perforation. an in vitro study

Content Provider	IEEE Xplore Digital Library
Author	Wylie, M.P. McGuinness, G.B. Gavin, G.P.
Copyright Year	2009
Description	Author affiliation: Dublin Institute of Technology's School of Manufacturing and Design Engineering, Dublin, Ireland (Wylie, M.P.; Gavin, G.P.) \|\| Dublin City University's School of Mechanical and Manufacturing Engineering, Dublin, Ireland (McGuinness, G.B.)
Abstract	The use of therapeutic ultrasound delivered via small diameter wire waveguides may represent an emerging minimally invasive approach in the treatment of chronic total occlusions (CTOs), calcified and fibrous plaques. The distal-tip mechanical vibrations (typically 0–210 µm peak-to-peak) have been reported to debulk rigid calcified and fibrous tissues while healthy elastic arterial tissue remains largely unaffected. The risk of arterial (healthy tissue) perforation with energized waveguides is not fully understood. An ultrasonic apparatus capable of delivering a range of wire waveguide distal-tip displacements, up to 80 µm peak-to-peak (p-p), at an operational frequency of 22.5 KHz (+/− 6%) has been developed. For three distal-tip displacement settings (32, 50 and 80 µm p-p) with 1.0 mm diameter waveguides, the force required to perforate healthy porcine aortic tissue was experimentally determined. The results show a distinct two stage perforation, thought to be the result of different mechanical properties of the layers in the arterial wall. The average maximum force (N) required to cause perforation with the 1.0 mm diameter ultrasonic waveguide activated at the three settings was experimentally determined to be 2.7 N (32 µm p-p), 2.6 N (50 µm p-p) and 2 N (80 µm p-p). The force required to cause perforation of the tissue with no ultrasound was found to be approximately 4 N. These results highlight that when ultrasound energy is applied to the waveguide, less force is required to perforate healthy arterial tissue. This reduction in perforation force is more pronounced at higher ultrasonic displacements, similar to those reported in clinical studies for the effective removal of diseased calcified and fibrous plaques.
Starting Page	282
Ending Page	285
File Size	944689
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334036
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Angioplasty In vitro Wire Minimally invasive surgery Arteries Frequency Cardiovascular diseases Lesions Manufacturing
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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