NDLI: Measurement of upper limb kinematics and joint angle patterns during deep brain stimulation for parkinson’s disease

Content Provider	IEEE Xplore Digital Library
Author	Khandwala, V.J. Burack, M.A. Mink, J.W. Gdowski, G.T. Gdowski, M.J.
Copyright Year	2009
Description	Author affiliation: Dept. Biomedical Eng., and Neurobiology & Anatomy, Univ. Rochester (Gdowski, G.T.) \|\| Dept. Neurology, Univ. Rochester (Burack, M.A.; Mink, J.W.) \|\| Dept. Biomedical Eng., Univ. Rochester (Khandwala, V.J.) \|\| Dept Neurobiology & Anatomy, Univ. Rochester, Rochester NY 14642 (Gdowski, M.J.)
Abstract	Therapeutic benefits of subthalamic nucleus (STN) deep brain stimulation (DBS) for motor symptoms of Parkinson’s disease (PD) are well-documented. However, the mechanisms underlying motor improvement with DBS remain poorly understood. We tested the hypothesis that STN-DBS-related improvements in voluntary arm movement kinematics are mediated by changes in the velocity and temporal sequencing of proximal joint angles. We evaluated a 56 year old male and 66 year old female with idiopathic Parkinson’s disease chronically implanted with bilateral STN-DBS. Patients performed a button press task while off medication in the DBS-on and DBS-off conditions. Movements of the upper limb were recorded using a 3D motion analysis system, and detailed kinematic measures were obtained for the arm and forearm. As expected, reaction and movement times were improved in the DBS-on compared to DBSoff condition. The two subjects differed with regards to the magnitude of their changes in peak linear velocity and peak angular velocities (shoulder flexion extension, shoulder abduction adduction and elbow flexion extension). Surprisingly, both PD patients increased the frequency with which they used a preferred sequence of shoulder and elbow joint activations when in the DBS-on condition. This preferred pattern was adopted with twice the frequency than in the DBS-off condition, and with increased frequency relative to a control group of 9 age-matched controls. These results suggest that STN-DBS may improve movement execution at the cost of flexibility in movement execution strategy.
Starting Page	1553
Ending Page	1556
File Size	411286
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5332399
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Kinematics Brain stimulation Parkinson's disease Shoulder Frequency Satellite broadcasting Elbow Testing Motion analysis Motion measurement
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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