NDLI: Respiration triggered magnetic drug targeting in the lungs

Content Provider	IEEE Xplore Digital Library
Author	Dahmani, C. Gotz, S. Weyh, T. Renner, R. Rosenecker, M. Rudolph, C.
Copyright Year	2009
Description	Author affiliation: Ludwig-Maximilians-Universität, Department of Pediatrics, Munich, Germany (Renner, R.; Rosenecker, M.; Rudolph, C.) \|\| Technische Universität München, Heinz Nixdorf-Lehrstuhl für Medizinische Elektronik, Munich, Germany (Dahmani, C.; Gotz, S.; Weyh, T.)
Abstract	Lung cancer kills per year 1.3 million people worldwide. It is the most fatal cancer type as far as men are concerned and the second deadliest for women. One of the recent technologies to treat carcinomas in the lungs consists in delivering drugs through the pulmonary pathways directly to the tumor cells over actively loaded superparamagnetic nanoparticles that are encapsulated in aerosols and guided by external magnetic fields. However, first implementations of this technique assumed a continuous application of the magnetic field all through the inspiration and expiration phases of the artificial respiratory act that supplies the patient. We observed that applying the field this way forced the magnetic aerosols to sediment at regions far from the target, mainly in the trachea and main bronchioles, because of the force inducing magnetic field gradients that are present over the whole field application area. We developed an approach to avoid this effect by punctually generating the aerosol cloud exactly at the beginning of the inspiration phase, which would propel the particles to the deepest parts of the lung and therefore to the targeted cells as well, and by synchronizing the magnetic field activation with the breathing process. Our developed system analyzes the relevant respiration parameters such as pressure and flow and detects the end of the inspiration phase to trigger the magnet exactly at that point in time, when particles have reached the deepest alveoli, including the targeted zones, and do not experience forces due to the streaming any more. The magnetic field is then held on during the expiration phase to assure the retention of the aerosols at the targeted sites, which increases the efficiency and focality of the treatment. This way, only target cells are subjected to the deposition of the drug carrying aerosols, while the other healthy regions of the lungs remain unaltered by side effects.
Starting Page	5440
Ending Page	5443
File Size	1716685
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5332476
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Lungs Aerosols Magnetic fields Cancer Pharmaceutical technology Tumors Nanoparticles Sediments Clouds breath triggering magnetic drug targeting superparamagnetic nanoparticles aerosols deposition
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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