NDLI: Computational modeling of cardiac dual calcium-voltage optical mapping

Content Provider	IEEE Xplore Digital Library
Author	Walton, R.D. Bernus, O.
Copyright Year	2009
Description	Author affiliation: Multidisciplinary Cardiovascular Research Centre and the Institute of Membrane and Systems Biology at the University of Leeds (Walton, R.D.; Bernus, O.)
Abstract	Optical imaging allows mapping the complex spatiotemporal dynamics of transmembrane potential and intracellular calcium in cardiac tissue. Several studies have shown that the epi-fluorescent optical action potential contains contributions from the sub-epicardium, owing to scattering of photons in tissue. Hybrid electro-optical models have allowed careful quantification of these scattering effects and have lead to a better interpretation of the optical action potential. However, until now, these effects have not been investigated for optically recorded calcium transients. Here, we develop a hybrid model of cardiac dual calcium-voltage epi-fluorescence mapping. This model allows simulating both optical action potentials and optical calcium transients and investigating the effects of photon scattering on their synthesis. We find that optical calcium transients contain contributions from sub-epicardial layers up to 0.8 mm below the epicardium. These lead to significant differences in rise time and activation times between the optically acquired calcium signal and the epicardial intracellular calcium concentration. As has been the case with optically recording action potentials, these results should be taken into account in the interpretation of experimental optical measurements of intracellular calcium.
Starting Page	2827
Ending Page	2830
File Size	569148
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5333576
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computational modeling Optical scattering Biomedical optical imaging Optical sensors Calcium Optical recording Voltage Light scattering Particle scattering Fluorescence
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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