NDLI: Quantitative investigation of bone microvascularization from 3D synchrotron micro-computed tomography in a rat model

Content Provider	IEEE Xplore Digital Library
Author	Langer, M. Prisby, R. Peter, Z. Boistel, R. Lafage-Proust, M. Peyrin, F.
Copyright Year	2009
Description	Author affiliation: Université de Lyon, St-Etienne, F-42023 France; Inserm, U890, F-42023 France (Prisby, R.; Lafage-Proust, M.) \|\| ESRF and Museum National d'Histoire Naturelle, Départ. EGB, CNRS UMR 7179, 57 rue Cuvier, F-75231 Paris, France (Boistel, R.) \|\| CREATIS-LRMN, CNRS UMR 5220; INSERM U630; Université de Lyon; INSA Lyon, F69621 Villeurbanne Cedex, France, and the European Synchrotron Radiation Facility, 6 rue Jules Horowitz, F38043 Grenoble, France (Langer, M.; Peyrin, F.) \|\| CREATIS-LRMN and is now with University of Paris 10, PST/IUT of Ville d'Avray, GTE Department, 50 Rue de Sèvres, F-92410 Ville d'Avray, France (Peter, Z.)
Abstract	A new method for simultaneous 3D imaging and analysis of microvascularization and bone microstructure in rat bone is developed. The method is based on the use of quantitative synchrotron micro-computed tomography (SR-µCT) coupled to an automatic image analysis procedure. Analysis of bone microvascularization is generally performed from 2D histology. The proposed method enables for the first time the simultaneous 3D analysis of microvascularization and bone microstructure in a rat model. It was applied to investigate the effect of intermittent parathyroid hormone (PTH) administration on angiogenesis and osteogenesis in rats. Rats were posthumously injected with a contrast agent and subsequently imaged. The algorithm allowed the reconstruction and the extraction of 3D quantitative parameters both on bone microstructure and microvascularization. Due to the short acquisition times of SR-µCT and the efficiency of the image analysis algorithm, a large data set was analyzed, which permitted statistical analysis of the measured parameters. Statistical analysis confirmed that treatment with PTH significantly increased bone volume and thickness, but decreased bone mineralization. It was further revealed that treatment with PTH significantly increased average vessel thickness.
Starting Page	1004
Ending Page	1007
File Size	1659769
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5333832
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bones Synchrotrons Tomography Image analysis Microstructure Rats Statistical analysis Performance analysis Biochemistry Image reconstruction
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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