NDLI: Effect of the coating morphology on the drug release from engineered drug-polymer nanocomposites

Content Provider	IEEE Xplore Digital Library
Author	Jinping Dong Frethem, C. Haugstad, G. Hoerr, R.A. Foley, J.D. Matuszewski, M.J. Puskas, J.E.
Copyright Year	2009
Description	Author affiliation: Nanocopoeia, Inc., 1246 West University Avenue, Suite 463, St. Paul, MN 55104 (Hoerr, R.A.; Foley, J.D.; Matuszewski, M.J.) \|\| Department of Polymer Science, The University of Akron, Akron, OH 44325 (Puskas, J.E.) \|\| Characterization Facility, Institute of Technology, University of Minnesota, 12 Shepherd Labs, 100 Union St SE, Minneapolis, MN 55455 (Jinping Dong; Frethem, C.; Haugstad, G.)
Abstract	The ElectroNanospray™ process (Nanocopoeia, Inc) transforms drugs and polymers into many nanoscale material states including powders, liquids, encapsulated particles, and coatings. This enabling technology platform allows application of polymers and drugs to the surface of medical devices such as coronary stents in a single-stage process. Modification of ElectroNanospray process parameters resulted in surface coatings with rich morphologies ranging in appearance from smooth and heterogeneous to highly porous and rough (open matrix). The traditional approach of measuring percent release over time by HPLC shows that the drug release profiles change significantly with coating morphology. In this study, we employed high resolution imaging techniques such as SEM, Atomic Force Microscopy (AFM) and Confocal Raman Microscopy to elucidate the drug release process on these coatings in situ, indicating a correlation of release kinetics with coating morphology.
Starting Page	6006
Ending Page	6009
File Size	1117821
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5332670
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Coatings Drugs Nanocomposites Scanning electron microscopy Atomic force microscopy Rough surfaces Surface roughness Surface morphology Biomedical engineering Polymer films
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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