NDLI: Ultrasound elastography to determine the layered mechanical properties of articular cartilage and the importance of such structural characteristics under load

Content Provider	IEEE Xplore Digital Library
Author	McCredie, A.J. Stride, E. Saffari, N.
Copyright Year	2009
Description	Author affiliation: Department of Mechanical Engineering, Torrington Place, London, WC1E 7JE (McCredie, A.J.) \|\| University College London, Department of Mechanical Engineering (Stride, E.; Saffari, N.)
Abstract	Articular cartilage is an important load bearing surface in joints. Prone to damage and with limited self-repair ability, it is of interest to tissue engineers. Tissue implant design requires full mechanical characterisation of healthy native tissue. A layered organisation of reinforcing collagen fibrils exists in healthy articular cartilage and is believed to be important for correct tissue function. However, the effect of this on the local depth-dependent elasticity is poorly characterised. In this study, quasi-static ultrasound elastography is used both to compare the depth-dependent elastic properties of cartilage structures with two different fibril arrangements and to monitor changes in the elastic properties of engineered samples during development. Results show global and local elastic properties of the native tissues and highlight the differences caused by fibril architecture. At increasing culture periods, results from the engineered tissue demonstrate an increase in elastic stiffness and the time taken to reach equilibrium under a quasi-static displacement. The study suggests suitability of ultrasound elastography for design and monitoring engineered articular cartilage.
Starting Page	4262
Ending Page	4265
File Size	744612
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334589
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Mechanical factors Cartilage Capacitive sensors Testing Joints Monitoring Mechanical engineering Design engineering Strain measurement
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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