NDLI: Effect of isoflurane on aortic impedance in mice

Content Provider	IEEE Xplore Digital Library
Author	Reddy, A.K. Namiranian, K. Lloyd, E.E. Bryan, R.M. Taffet, G.E. Hartley, C.J.
Copyright Year	2009
Description	Author affiliation: Department of Medicine, Section of Cardiovascular Sciences, Baylor College of Medicine and The Methodist DeBakey Heart & Vascular Center, Houston, TX 77030 (Reddy, A.K.; Taffet, G.E.; Hartley, C.J.) \|\| Department of Anesthesiology at Baylor College of Medicine (Namiranian, K.; Lloyd, E.E.; Bryan, R.M.)
Abstract	Isoflurane is the most commonly used anesthetic in mice. We studied the effect of low and high levels of isoflurane (also a potent coronary vasodilator) on aortic impedance in mice. Aortic impedance was determined using pressure and flow velocity signals at baseline (B, pentobarbital anesthesia), low (Isol, 1%), and high (Iso2.5, 2.5%) levels of isoflurane. Significant differences were observed in peak and mean flow velocities, systolic, diastolic, mean and pulse pressures at B and Iso2.5. However in impedance indices only peripheral vascular resistance was significantly different. No changes were observed in the harmonic components that represent pulsatile characteristics of the aorta. Peak left ventricular (LV) pressure was significantly lower at Iso2.5 when compared to B, but ±dP/dt and τ (time constant of LV relaxation) did not change significantly indicating that LV contractility was unaffected. These results show that various levels of isoflurane cause significant changes in vascular hemodynamics and care must be taken to minimize these differences when using isoflurane as an anesthesia.
Starting Page	1104
Ending Page	1105
File Size	379715
Page Count	2
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334387
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Impedance Mice Anesthesia Hemodynamics Catheters Velocity measurement Pressure measurement Blood pressure Anesthetic drugs Arteries LV contractility Aortic impedance Aortic pressure Aortic flow velocity
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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