NDLI: Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye

Content Provider	IEEE Xplore Digital Library
Author	Downs, J.C. Roberts, M.D. Burgoyne, C.F. Hart, R.T.
Copyright Year	2009
Description	Author affiliation: Ocular Biomechanics Laboratory, Devers Eye Institute, Portland, OR 97232 USA (Roberts, M.D.) \|\| Biomedical Engineering Department, The Ohio State University, Columbus, OH 43210 USA (Hart, R.T.) \|\| Ocular Biomechanics Laboratory, Devers Eye Institute, 1225 NE 2nd Avenue, Portland, OR 97232 USA (Downs, J.C.) \|\| Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, OR 97232 USA (Burgoyne, C.F.)
Abstract	In this paper, we describe a new method for constructing macro-scale models of the posterior pole of the eye to investigate the role of intraocular pressure in the development and progression of glaucoma. We also describe a method and present results from micro-scale finite element models of the lamina cribrosa microarchitecture that are derived from parent macro-scale continuum models using a novel multiscale substructuring approach. The laminar micro-scale models capture the biomechanical behavior of the laminar trabeculae in a way that cannot be estimated using macro-scale techniques, and predict much higher stresses and strains than those calculated within macro-scale models of the coincident region in the same eye.
Starting Page	4277
Ending Page	4280
File Size	1933281
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5332755
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Finite element methods Microarchitecture Image reconstruction Connective tissue Nerve fibers Biomechanics Laboratories Predictive models Irrigation Biomedical optical imaging
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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