NDLI: Cell-matrix mechanobiology: Applications to brain tumors and design of tissue engineering scaffolds

Content Provider	IEEE Xplore Digital Library
Author	Kumar, S.
Copyright Year	2009
Description	Author affiliation: Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720 USA (Kumar, S.)
Abstract	It is becoming increasingly clear that mechanical and other biophysical signals from the extracellular matrix (ECM) can powerfully influence a wide variety of fundamental cell behaviors, including proliferation, differentiation, death, and motility. This concept has significant implications both for understanding the pathophysiology of disease and the design of biointerfaces found in cellular microdevices and tissue engineering platforms. Here we briefly review recent progress from our laboratory in investigating the role of ECM-derived mechanical signals in the specific context of two systems: The growth and spread of malignant brain tumors and the design of microscale cardiac tissue engineering systems. In both cases, mechanical signals encoded in the ECM govern motility, mechanics, and/or proliferation in profound and unexpected ways and rely upon the cell’s reciprocal ability to generate contractile force through myosin and its molecular regulators.
Starting Page	3350
Ending Page	3352
File Size	323932
Page Count	3
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5333188
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neoplasms Tissue engineering Electrochemical machining Extracellular Diseases Laboratories Cancer Signal design Cardiac tissue Design engineering
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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