NDLI: Simulation of a presynaptic nerve terminal with a tethered particle system model

Content Provider	IEEE Xplore Digital Library
Author	Goldstein, R. Wainer, G.
Copyright Year	2009
Description	Author affiliation: Department of Systems and Computer Engineering at Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada (Goldstein, R.; Wainer, G.)
Abstract	Presynaptic nerve terminals are located at the ends of nerve cells; a signal propagating through a nerve cell reaches one of these compartments before being transmitted to an adjacent nerve cell. A tethered particle system (TPS) is a type of impulse-based model recently developed for the simulation of deformable biological structures. In a TPS, collisions can cause approaching particles to rebound outwards, as one would expect, but they can also caused separating particles to retract inwards. This paper demonstrates how a TPS can be used to simulate biological systems by presenting its application to a presynaptic nerve terminal. The model captures the clustering of sacs called vesicles in the presence of protein called synapsin. Both rigid and deformable membranes are also described. The simulated presynaptic nerve terminal may be used, for example, to predict how a change in synapsin concentration affects the size of vesicle clusters.
Starting Page	3877
Ending Page	3880
File Size	966266
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5332639
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Biomembranes Deformable models Biological systems Cells (biology) Proteins Predictive models Neurotransmitters Chemicals Medical simulation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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