NDLI: Photochemical approach of photodynamic therapy applied to skin

Content Provider	IEEE Xplore Digital Library
Author	Fanjul-Velez, F. Salas-Garcia, I. Ortega-Quijano, N. Arce-Diego, J.L.
Copyright Year	2009
Description	Author affiliation: Applied Optical Techniques Group, TEISA Department, University of Cantabria (Fanjul-Velez, F.; Salas-Garcia, I.; Ortega-Quijano, N.; Arce-Diego, J.L.)
Abstract	Photodynamic Therapy (PDT) is a recent treatment modality that allows malignant tissue destruction. The technique provides a localized effect and good cosmetic results. The application of PDT is based on the inoculation of a photosensitizer and the posterior irradiation by an optical source. This radiation chemically activates the drug and provokes reactions that lead to tissue necrosis. Nowadays there are fixed clinical PDT protocols that make use of a particular optical dose and photosensitizer amount. These parameters are independent of the patient and the lesion. In this work we present a PDT model that tries to predict the effect of the treatment on the tissue. The 3D optical propagation of radiation is calculated by means of the Radiation Transport Theory (RTT) model, solved via a Monte Carlo numerical model. Once the optical energy is obtained, a complex photochemical model is employed. This model takes into account the electronic transitions between molecular levels and particles concentrations. The data obtained allow us to estimate the destroyed area. The optical power of the source, the exposition time and the optochemical characteristics of the tissue can be varied. This implies that these parameters could be adjusted to the particular pathology we are dealing with. As a consequence, the treatment would be more efficient. We apply the model to the skin, due to the fact that PDT is commonly applied on it.
Starting Page	278
Ending Page	281
File Size	342367
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334040
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Photochemistry Medical treatment Skin Cancer Chemicals Drugs Protocols Lesions Predictive models Optical propagation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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