NDLI: Deriving a blood-mimicking fluid for particle image velocimetry in sylgard-184 vascular models

Content Provider	IEEE Xplore Digital Library
Author	Yousif, M.Y. Holdsworth, D.W. Poepping, T.L.
Copyright Year	2009
Description	Author affiliation: Department of Physics and Astronomy, The University of Western Ontario, London, ON N6A 3K7 Canada (Poepping, T.L.) \|\| Biomedical Engineering Graduate Program, The University of Western Ontario, London, ON N6A 3K7 Canada (Yousif, M.Y.) \|\| Robarts Research Institute, P.O. Box 5015, 100 Perth Drive, London, Ontario N6A 5K8, Canada (Holdsworth, D.W.)
Abstract	A new blood-mimicking fluid (BMF) has been developed for particle image velocimetry (PIV), which enables flow studies in vascular models (phantoms). A major difficulty in PIV that affects measurement accuracy is the refraction and distortion of light passing through the interface between the model and the fluid, due to the difference in refractive index (n) between the two materials. The problem can be eliminated by using a fluid with a refractive index matching that of the model. Such fluids are not commonly available, especially for vascular research where the fluid should also have a viscosity similar to human blood. In this work, a blood-mimicking fluid, composed of water (47.38% by weight), glycerol (36.94% by weight) and sodium iodide salt (15.68% by weight), was developed for compatibility with our silicone (Sylgard 184; n = 3D 1.414) phantoms. The fluid exhibits a dynamic viscosity of 4.31±0.03 cP which lies within the range of human blood viscosity (4.4±0.6 cP). Both refractive index and viscosity were attained at 22.2±0.2 $^{◦}C,$ which is a feasible room temperature, thus eliminating the need for a temperature-control system. The fluid will be used to study hemodynamics in vascular flow models fabricated from Sylgard 184.
Starting Page	1412
Ending Page	1415
File Size	504729
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334175
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Viscosity Refractive index Imaging phantoms Humans Blood Distortion measurement Optical refraction Fluid dynamics Temperature Hemodynamics
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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