NDLI: An ultra-sensitive ∆R/R measurement system for biochemical sensors using piezoresistive micro-cantilevers

Content Provider	IEEE Xplore Digital Library
Author	Sudip Nag Kale, N.S. Rao, V.R. Sharma, D.K.
Copyright Year	2009
Description	Author affiliation: Electrical Engineering Department, Indian Institute of Technology Mumbai, India (Sudip Nag; Kale, N.S.; Rao, V.R.; Sharma, D.K.)
Abstract	Piezoresistive micro-cantilevers are interesting bio-sensing tool whose base resistance value (R) changes by a few parts per million (∆R) in deflected conditions. Measuring such a small deviation is always being a challenge due to noise. An advanced and reliable ∆R/R measurement scheme is presented in this paper which can sense resistance changes down to 6 parts per million. The measurement scheme includes the half-bridge connected micro-cantilevers with mismatch compensation, precision op-amp based filters and amplifiers, and a lock-in amplifier based detector. The input actuating sine wave is applied from a function generator and the output dc voltage is displayed on a digital multimeter. The calibration is performed and instrument sensitivity is calculated. An experimental set-up using a probe station is discussed that demonstrates a combined performance of the measurement system and SU8-polysilicon cantilevers. The deflection sensitivity of such polymeric cantilevers is calculated. The system will be highly useful to detect bio-markers such as myoglobin and troponin that are released in blood during or after heart attacks.
Starting Page	3794
Ending Page	3797
File Size	1322995
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334434
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biosensors Piezoresistance Electrical resistance measurement Operational amplifiers Immune system Noise measurement Filters Detectors Signal generators Voltage myoglobin ∆R/R measurement Polymeric micro-cantilever piezoresistor lock-in amplifier probe station deflection sensitivity
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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