NDLI: Interactions of nanoparticles with lipid vesicles: A population based computer aided image analysis approach

Content Provider	IEEE Xplore Digital Library
Author	Zupanc, J. Valant, J. Dobnikar, A. Kralj-Iglic, V. Iglic, A. Drobne, D.
Copyright Year	2009
Description	Author affiliation: Biotechnical Faculty Ljubljana, all with University of Ljubljana, Slovenia (Valant, J.; Drobne, D.) \|\| Faculty of Electrical Engineering, all with University of Ljubljana, Slovenia (Iglic, A.) \|\| Faculty of Medicine, all with University of Ljubljana, Slovenia (Kralj-Iglic, V.) \|\| Faculty of Computer and Information Science, all with University of Ljubljana, Slovenia (Zupanc, J.; Dobnikar, A.)
Abstract	Novel properties of nanoparticles have numerous potential technological applications but at the same time they underlie new kinds of biological effects. Uniqueness of nanoparticles and nanomaterials requires a new experimental methodology. Much evidence suggests that nanoparticles affect cell membrane stability and subsequently exert toxic effects. For this kind of research, lipid vesicles are of high value due to controllability and repeatability of experimental conditions. The aim of work presented here was to develop a computer aided analysis of lipid vesicles shape transformations. We studied a population of palmitoyloleoylphosphatidylcholine (POPC) lipid vesicles after exposure to nanoparticles (C60) or a reference chemical (ZnCl2). With the use of computer image analysis methods, we detected differences in size distributions of vesicles in different exposure groups. Though, at the present state, we are not able to precisely identify effects of nanoparticles on shape transformations of vesicles, those incubated with nanoparticles were in average larger than those in other groups. This population based approach holds many promises for future investigation of nanoparticles-lipid vesicles, or even nanoparticles-biological membranes interactions. However, in order to get reliable results, numerous images have to be analyzed which requires improved and highly automated image segmentation and analyses methods.
Starting Page	1400
Ending Page	1403
File Size	481094
Page Count	4
File Format	PDF
ISBN	9781424432967
ISSN	1557170X
DOI	10.1109/IEMBS.2009.5334153
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanoparticles Lipidomics Image analysis Biomembranes Shape Nanobioscience Biology computing Application software Nanomaterials Cells (biology)
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Analysis of lipid vesicle populations from microscopy video sequences

Automated Angiogenesis Quantification through advanced Image Processing Techniques

Portable nanoparticle quantization using a resizable nanopore instrument - The IZON qNano™

Planar lipid bilayers: Observing pore creation and extinction

Modeling the effects of nanoparticles on neuronal cells: From ionic channels to network dynamics

Construction and Characterization of Soft-Supported Lipid Bilayer Membranes for Biosensors Application

Modulation of platelet membrane function via exogenous lipid moiety exposure alters platelet responsiveness to shear

Multiscale data reduction with flexible saliency criterion for biological image analysis

Effect of fluorescent tags on translocation through nanochannels

Interactions of nanoparticles with lipid vesicles: A population based computer aided image analysis approach

Similar Documents

Analysis of lipid vesicle populations from microscopy video sequences

Automated Angiogenesis Quantification through advanced Image Processing Techniques

Portable nanoparticle quantization using a resizable nanopore instrument - The IZON qNano™

Planar lipid bilayers: Observing pore creation and extinction

Modeling the effects of nanoparticles on neuronal cells: From ionic channels to network dynamics

Construction and Characterization of Soft-Supported Lipid Bilayer Membranes for Biosensors Application

Modulation of platelet membrane function via exogenous lipid moiety exposure alters platelet responsiveness to shear

Multiscale data reduction with flexible saliency criterion for biological image analysis

Effect of fluorescent tags on translocation through nanochannels

Interactions of nanoparticles with lipid vesicles: A population based computer aided image analysis approach