NDLI: Non-linear stress-strain measurements of ex vivo produced oral mucosal equivalent (EVPOME) compared to normal oral mucosal and skin tissue

Content Provider	IEEE Xplore Digital Library
Author	Winterroth, Frank Hollister, Scott J. Feinberg, Stephen E. Kuo, Shiuhyang Fowlkes, J. Brian Ganguly, Arindam Hollman, Kyle W.
Copyright Year	2011
Description	Author affiliation: Sound Sight Research, LLC, Livonia, MI 48152 USA (Hollman, Kyle W.) \|\| Department of Biomedical Engineering, Department of Mechanical Engineering and the Department of Surgery at the University of Michigan, Ann Arbor, MI 48109 USA (Hollister, Scott J.) \|\| Department of Chemistry at the University of Michigan, Ann Arbor, MI 48109 USA (Ganguly, Arindam) \|\| Department of Oral and Maxillofacial Surgery at the University of Michigan, Ann Arbor, MI 48109 USA (Kuo, Shiuhyang) \|\| Department of Radiology and the Department of Biomedical Engineering at the University of Michigan, Ann Arbor, MI 48109 USA (Fowlkes, J. Brian) \|\| Department of Oral and Maxillofacial Surgery and the Department of Biomedical Engineering at the University of Michigan, Ann Arbor, MI 48109 USA (Feinberg, Stephen E.) \|\| Department of Biomedical Engineer at the University of Michigan, Ann Arbor, MI 48109 USA (Winterroth, Frank)
Abstract	Stress-strain curves of oral mucosal tissues were measured using direct mechanical testing. Measurements were conducted on both natural oral mucosal tissues and engineered devices, specifically a clinically developed ex vivo produced oral mucosal equivalent (EVPOME). As seeded cells proliferate on EVPOME devices, they produce a keratinized protective upper layer which fills in surface irregularities. These transformations can further alter stress-strain parameters as cells in EVPOME differentiate, more similar to natural oral mucosal tissues in contrast to an unseeded scaffold. In addition to tissue devices grown under normal conditions (37°C), EVPOMEs were also produced at 43°C. These thermally stressed specimens model possible failure mechanisms. Results from a mechanical deformation system capable of accurate measurements on small (approximately 1.0–1.5 $cm^{2})$ cylindrical tissue samples are presented. Deformations are produced by lowering a circular piston, with a radius smaller than the sample radius, onto the center of the sample. Resulting force is measured with a precision electronic balance. Cultured EVPOME was less stiff than AlloDerm®, but similar to native porcine buccal tissue. Porcine skin and porcine palate tissues were even less stiff. Thermally stressed EVPOME was less stiff than normally cultured EVPOME as expected because stressed keratin cells were damaged reducing the structural integrity of the tissue.
Starting Page	286
Ending Page	289
File Size	492739
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090075
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Thermal stresses Biomedical measurements Stress Mechanical variables measurement Skin Elasticity
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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