NDLI: A 1μm diameter tip fiber-based surface plasmon resonance system for single unit optical neural recording

Content Provider	IEEE Xplore Digital Library
Author	Moon, Hyowon Kim, Shin Ae Jun, Sang Beom Lee, Jesun Oh, Uhtaek Kim, Sung June
Copyright Year	2011
Description	Author affiliation: School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea (Moon, Hyowon; Kim, Shin Ae; Kim, Sung June) \|\| Collage of Pharmacy, Seoul National University, Seoul, Republic of Korea (Lee, Jesun; Oh, Uhtaek) \|\| Division of Electronics Engineering, Ewha Womans University, Seoul, Republic of Korea (Jun, Sang Beom)
Abstract	A gold-deposited optical fiber sensor system based on surface plasmon resonance (SPR) was developed for optical measurement of neuronal activity. To enhance the sensitivity of localized SPR and to make a precise and safe contact with the cellular membrane, we designed a tapered optical probe of 1μm diameter at the tip of the fiber. By wet etching and gold evaporating processes, pencil-shaped optical probes were successfully fabricated. The SPR system with the sharp optical probe was integrated with a conventional patch clamping system to realize a simultaneous optical and electrical recording on a single neuron. Although the shape of optical signal is not clear due to tiny change of intrinsic optical properties on the neuron, optical and electrical signals were simultaneously changed by capsaicin stimulation. Furthermore, our designed fiber probe can be applicable to localized optical stimulation as well as in vivo optical neuroprosthetic devices.
Starting Page	498
Ending Page	500
File Size	692895
Page Count	3
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090089
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical fiber sensors Optical recording Optical device fabrication Optical fiber couplers
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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