NDLI: Effect of self-gating on action potential firing at neuromuscular junction

Content Provider	IEEE Xplore Digital Library
Author	Rahman, M.M. Mahmud, M. Vassanelli, S.
Copyright Year	2011
Description	Author affiliation: NeuroChip Laboratory of Department of Human Anatomy & Physiology and Department of Information Engineering, University of Padova, 35131, Padova, Italy (Rahman, M.M.) \|\| NeuroChip Laboratory of Department of Human Anatomy & Physiology, University of Padova, 35131, Padova, Italy (Mahmud, M.; Vassanelli, S.)
Abstract	The neuromuscular junction (NMJ) is the place where the axon terminal of motoneuron connects the ‘endplate’ of a muscle fiber. During this transduction a large depolarization (endplate potential) caused by the nerve impulse opens a large number of voltage-sensitive sodium channels at the post-junctional terminal. As a result, action potentials are generated and propagated along the muscle fiber causing contraction. This work shows simulated results of the voltage-dependent sodium channels' firing behavior at the NMJ using a mathematical model. It is found that the firing behavior of the sodium channels change basing on their activation and inactivation kinetics which are highly influenced by the self-gating behavior of the sodium conductances. The simulation results showed that self-gating of sodium channels increase conduction efficiency at the NMJ and decrease threshold for firing.
Starting Page	4082
Ending Page	4085
File Size	771955
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6091014
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Firing Electric potential Junctions Neuromuscular Nerve fibers Kinetic theory action potentials Self-gating voltage-dependent sodium channels neuromuscular junction
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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