NDLI: Selective co-stimulation of pudendal afferents enhances reflex bladder activation

Content Provider	IEEE Xplore Digital Library
Author	McGee, Meredith J. Yoo, Paul B. Grill, Warren M.
Copyright Year	2011
Description	Author affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708 USA (McGee, Meredith J.; Yoo, Paul B.) \|\| Departments of Biomedical Engineering, Neurobiology, and Surgery, Duke University, Durham, NC 27708 USA (Grill, Warren M.)
Abstract	The loss of normal bladder function is common in persons with spinal cord injury (SCI) and negatively impacts their quality of life. Electrical stimulation of pudendal nerve afferents is a promising approach to restore control of bladder function. Pudendal afferent stimulation can generate reflex contraction of the bladder, but the resulting bladder voiding efficiency remains low. The objective of this work was t o evaluate selective co-stimulation of two branches of the pudendal nerve — the cranial urethral sensory nerve (CSN) and the dorsal nerve of the penis (DNP) — as a means to enhance reflex bladder activation and bladder voiding efficiency. In preclinical studies in anesthetized adult cats, co-stimulation of CSN and DNP evoked larger bladder contractions than individual stimulation of either CSN or DNP. In a parallel clinical experiment involving a participant with chronic SCI, co-stimulation of the proximal and distal urethra also produced synergistic augmentation of reflex bladder activity, and thus improved voiding efficiency when compared to reflex distension-evoked voiding. Selective co-stimulation of pudendal afferents is efficacious and should be considered in the development of neural prosthetics for restoration of bladder function in persons with SCI.
Starting Page	1057
Ending Page	1060
File Size	666089
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090246
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bladder Electrodes Cats Catheters Humans Electrical stimulation Spinal cord injury
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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Selective Co-stimulation of Pudendal Afferents Enhances Reflex Bladder Activation

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