NDLI: Frank-starling control of a left ventricular assist device

Content Provider	IEEE Xplore Digital Library
Author	Stevens, M.C. Gaddum, N.R. Pearcy, M. Salamonsen, R.F. Timms, D.L. Mason, D.G. Fraser, J.F.
Copyright Year	2011
Description	Author affiliation: School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Australia (Stevens, M.C.; Mason, D.G.) \|\| Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Australia (Salamonsen, R.F.) \|\| Critical Care Research Group, The Prince Charles Hospital, University of Queensland, Brisbane, Australia (Gaddum, N.R.; Timms, D.L.; Fraser, J.F.) \|\| Institute of Healthy and Biomedical Innovation and the Faculty of Built Environment and Engineering at Queensland University of Technology, Brisbane, Australia (Pearcy, M.)
Abstract	A physiological control system was developed for a rotary left ventricular assist device (LVAD) in which the target pump flow rate (LVADQ) was set as a function of left atrial pressure (LAP), mimicking the Frank-Starling mechanism. The control strategy was implemented using linear PID control and was evaluated in a pulsatile mock circulation loop using a prototyped centrifugal pump by varying pulmonary vascular resistance to alter venous return. The control strategy automatically varied pump speed (2460 to 1740 to 2700 RPM) in response to a decrease and subsequent increase in venous return. In contrast, a fixed-speed pump caused a simulated ventricular suction event during low venous return and higher ventricular volumes during high venous return. The preload sensitivity was increased from 0.011 L/min/mmHg in fixed speed mode to 0.47L/min/mmHg, a value similar to that of the native healthy heart. The sensitivity varied automatically to maintain the LAP and LVADQ within a predefined zone. This control strategy requires the implantation of a pressure sensor in the left atrium and a flow sensor around the outflow cannula of the LVAD. However, appropriate pressure sensor technology is not yet commercially available and so an alternative measure of preload such as pulsatility of pump signals should be investigated.
Starting Page	1335
Ending Page	1338
File Size	935087
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090314
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sensitivity Heart Control systems Blood Biomedical monitoring Australia Educational institutions
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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