NDLI: Unifying the integration, analysis and interpretation of multi-omic datasets: Exploration of the disease networks of Obstructive Nephropathy in children

Content Provider	IEEE Xplore Digital Library
Author	Moulos, P. Valavanis, I. Klein, J. Maglogiannis, I. Schanstra, J. Chatziioannou, A.
Copyright Year	2011
Description	Author affiliation: Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece (Moulos, P.; Valavanis, I.; Chatziioannou, A.) \|\| Institut National de la Santé et de la Recherche Médicale (INSERM), U858, Toulouse, France (Klein, J.; Schanstra, J.) \|\| University of Central Greece, Lamia, Greece (Maglogiannis, I.)
Abstract	The wealth of data amassed by the utilization of various high-throughput techniques, in various layers of molecular dissection, stresses the critical role of the unification of the computational methodologies applied in biological data handling, storage, analysis and visualization. In this article, a generic workflow is showcased in a multi-omic dataset that is used to study Obstructive Nephropathy (ON) in children, integrating microarray data from several biological layers (transcriptomic, post-transcriptomic, proteomic). The workflow exploits raw measurements and through several analytical stages (preprocessing, statistical and functional), which entail various parsing steps, reaches the visualization stage of the heterogeneous, broader, molecular interacting network derived. This network, where the interconnected entities are exploiting the knowledge stored in public repositories, represents a systems level interpretation of the pathological state probed.
Starting Page	3716
Ending Page	3719
File Size	534620
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090631
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Data visualization Proteins Bioinformatics Mice Genomics Proteomics
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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